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KMID : 0380620070390040470
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Korean Journal of Food Science and Technology
2007 Volume.39 No. 4 p.470 ~ p.475
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Fourteen-day Repeated-dose Oral Toxicity Study of the Ethanol Extracts Isolated from Oplopanax elatus in Sprague-Dawley Rat
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Kwon Hyuck-Se
Kim Dae-Hwan
Shin Hyun-Kyung
Yu Chang-Yeon
Kim Myong-Jo
Lim Jung-Dae
Park Jae-Kun
Kim Jin-Kyung
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Abstract
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Oplopanax elatus (O. elatus) is a tall deciduous shrub that has traditionally been used for treating a variety of ailments such as diabetes, coughing, rheumatism, gastro-intestinal disorders, and wounds. In order to examine the safety of the ethanol extracts of O. elatus, we performed a 14-day repeated-dose toxicity study with Sprague-Dawley rats. The rats were treated with daily doses of the O. elatus ethanol extracts by gavage at 0, 500, 1000, and 2000 mg/kg/day for 14 consecutive days. We recorded clinical signs of toxicity, body weight, hematology, organ weights, gross and histological changes in target organs, and clinical chemistry analysis data for all rats. There were no significant changes in body and organ weights during the experimental period. The hematological analysis and clinical blood chemistry data revealed no toxic effects from the O. elatus ethanol extracts. Pathologically, neither gross abnormalities nor histopathological changes were observed between the control and treated rats of both sexes. Collectively, these data suggest that the ethanol extracts of O. elatus have a high margin of safety.
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KEYWORD
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Oplopanax elatus, 14-day repeated-dose oral toxity, SD rat
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